In 2017 over 60,000 Americans died as the result of opioid overdoses, more than died annually in this country during the peak of the AIDs epidemic, more than die every year from breast cancer, and more Americans than died in the entire Vietnam War. But even though the overdose crisis ravaging our nation seems impossible to ignore, few understand how it came to be. OPIUM tells the extraordinary and at times harrowing story of how we arrived at today's crisis, a story that begins at the dawn of human civilization with enterprising poppy farmers in Mesopotamia, explores the breakthroughs of too-often forgotten experimental chemists in the Arab world who first refined poppy juice into opium, of colonial powers who spirited opium around the world in the interest of building out empires, of psychiatrists like Freud who ushered opium into modern medicine, and finally the story of the pharmaceutical conglomerates we know today that used opium and its more potent cousin, heroin, as a model for a wave of pills that laid the groundwork for today's overdose epidemic.