As teenagers in Lagos, Ifemelu and Obinze fall in love. Their Nigeria is under military dictatorship, and people are fleeing the country if they can. The self-assured Ifemelu departs for America. There she suffers defeats and triumphs, finds and loses relationships, all the while feeling the weight of something she never thought of back home: race. Obinze had hoped to join her, but post-9/11 America will not let him in, and he plunges into a dangerous, undocumented life in London.

Thirteen years later, Obinze is a wealthy man in a newly democratic Nigeria, while Ifemelu has achieved success as a blogger. But after so long apart and so many changes, will they find the courage to meet again, face to face?