The War of Kings is over - now the universe must pay the price! A Fault in space-time has ripped open, and the terrifying Cancerverse lies on the other side! To seal the Fault, the cosmos' greatest heroes band together: the Imperial Guard, Inhumans, Nova Corps and Guardians of the Galaxy! New players join the celestial game, like the son of Hulk and the awesome Annihilators. But the Marvel Universe's fate may lie in the hands of one of its greatest villains...Thanos is back in a big way!